Introduction to Bioinformatics

PDF | English |6MB | 255pages


My goal is that readers of this book will emerge with
?? An appreciation of the nature of the very large amount of detailed information about ourselves and
other species that has become available.
?? A sense of the range of applications of bioinformatics to molecular biology, clinical medicine,
pharmacology, biotechnology, agriculture, forensic science, anthropology and other disciplines.
?? A useful knowledge of the techniques by which, through the World Wide Web, we gain access to
the data and the methods for their analysis.
?? An appreciation of the role of computers and computer science in the investigations and
applications of the data.
?? Confidence in the reader's basic skills in information retrieval, and calculations with the data, and in
the ability to extend these skills by self-directed 'field work' on the Web.
?? A sense of optimism that the data and methods of bioinformatics will create profound advances in
our understanding of life, and improvements in the health of humans and other living things.
Plan of the book
?? Chapter 1 sets the stage and introduces all of the major players: DNA and protein sequences and
structures, genomes and proteomes, databases and information retrieval, the World Wide Web and
computer programming. Before developing individual topics in detail it is important to see the
framework of their interactions.
?? Chapter 2 presents the nature of individual genomes, including the Human Genome, and the
relationships among them, from the biological point of view.
?? Chapter 3 imparts basic skills in using the Web in bioinformatics. It describes archival databanks,
and leads the reader through sample sessions, involving information retrieval from some of the major
databases in molecular biology.
?? Chapter 4 treats the analysis of relationships among sequences - alignments and phylogenetic
trees. These methods underlie some of the major computational challenges of bioinformatics:
detecting distant relatives, understanding relationships among genomes of different organisms, and
tracing the course of evolution at the species and molecular levels.
?? Chapter 5 moves into three dimensions, treating protein structure and folding. Sequence and
structure must be seen as full partners, with bioinformatics developing methods for moving back and
forth between them as fluently as possible. Understanding protein structures in detail is essential for
determining their mechanisms of action, and for clinical and pharmacological applications.


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